Remote actuation of synthetic cells by external force fields

This project focuses on the design, fabrication, and remote actuation of bioinspired micro-compartments as models of synthetic cells. Specifically, it explores the use of Janus-type emulsion droplets with asymmetric encapsulation of nanoparticles and bioactive cargoes. The work combines the synthesis and functionalization of nanoparticles with microfluidic generation of controlled droplets, enabling spatial compartmentalization. These systems are then actuated by external force fields to achieve controlled heating, enzymatic activation, motility, and transport, among others. Apart from single compartments, the project also would investigate collective behaviours such as fusion, exchange of contents, and spatial organization within populations of droplets. Overall, our research advances towards the development of adaptive synthetic cells and communities. Integrating external actuation with internal compartmentalization provides a promising route to provide synthetic cells with greater adaptiveness and autonomy, moving them closer to life-like systems capable of sustaining out-of-equilibrium behaviours.